Ontology highlight
ABSTRACT:
SUBMITTER: Aran D
PROVIDER: S-EPMC4757527 | biostudies-literature | 2016 Feb
REPOSITORIES: biostudies-literature
Aran Dvir D Abu-Remaileh Monther M Levy Revital R Meron Nurit N Toperoff Gidon G Edrei Yifat Y Bergman Yehudit Y Hellman Asaf A
PLoS genetics 20160217 2
Cancers often display gene expression profiles resembling those of undifferentiated cells. The mechanisms controlling these expression programs have yet to be identified. Exploring transcriptional enhancers throughout hematopoietic cell development and derived cancers, we uncovered a novel class of regulatory epigenetic mutations. These epimutations are particularly enriched in a group of enhancers, designated ES-specific enhancers (ESSEs) of the hematopoietic cell lineage. We found that hematop ...[more]