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Cutting edge in medical management of cutaneous oncology.

ABSTRACT: Traditional chemotherapy has resulted in only a modest response, if any, for the 3 most common cutaneous malignancies of basal cell carcinoma, squamous cell carcinoma, and melanoma. Recent advances in understanding of the defects in the pathways driving tumorigenesis have changed the way that we think of these cancers and paved the way to targeted therapy for specific tumors. In this review, we will introduce the novel systemic treatments currently available for these cancers in the context of what is understood about the tumor pathogenesis. We will also introduce ongoing studies that will hopefully broaden our options for highly effective and tolerable treatment.

SUBMITTER: Chong K

PROVIDER: S-EPMC3367308 | biostudies-other | 2012 Jun

REPOSITORIES: biostudies-other

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Cutting edge in medical management of cutaneous oncology.

Chong Kim K Daud Adil A Ortiz-Urda Susana S Arron Sarah T ST

Seminars in cutaneous medicine and surgery 20120601 2

Traditional chemotherapy has resulted in only a modest response, if any, for the 3 most common cutaneous malignancies of basal cell carcinoma, squamous cell carcinoma, and melanoma. Recent advances in understanding of the defects in the pathways driving tumorigenesis have changed the way that we think of these cancers and paved the way to targeted therapy for specific tumors. In this review, we will introduce the novel systemic treatments currently available for these cancers in the context of w ...[more]

PMID: 22640435

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