Ontology highlight
ABSTRACT:
SUBMITTER: Bajwa G
PROVIDER: S-EPMC4761472 | biostudies-literature | 2016 Mar
REPOSITORIES: biostudies-literature
Bajwa Gagan G DeBerardinis Ralph J RJ Shao Baomei B Hall Brian B Farrar J David JD Gill Michelle A MA
Journal of immunology (Baltimore, Md. : 1950) 20160129 5
Plasmacytoid dendritic cells (pDCs) are vital to antiviral defense, directing immune responses via secretion of huge concentrations of IFN-α. These cells are critical in protecting the lung against clinically relevant respiratory viruses, particularly influenza (Flu), a virus responsible for substantial worldwide morbidity and mortality. How pDC responses to such viral pathogens are regulated, however, is poorly understood in humans. Using an unbiased approach of gene chip analysis, we discovere ...[more]