Ontology highlight
ABSTRACT:
SUBMITTER: Kreisel D
PROVIDER: S-EPMC3897247 | biostudies-literature | 2010 Oct
REPOSITORIES: biostudies-literature
Kreisel Daniel D Richardson Steven B SB Li Wenjun W Lin Xue X Kornfeld Christopher G CG Sugimoto Seiichiro S Hsieh Chyi-Song CS Gelman Andrew E AE Krupnick Alexander S AS
Journal of immunology (Baltimore, Md. : 1950) 20100901 7
The interaction of CD4(+) T cells with MHC class II (MHCII)-expressing hematopoietic APCs plays a critical role in both the generation of protective immune responses and maintenance of tolerance in the lung. The functional significance of MHCII expression by nonhematopoietic stromal cells, however, has not been defined in vivo. Using a novel mouse model of orthotopic left lung transplantation, we demonstrate that selective elimination of MHCII expression on nonhematopoietic cells leads to an inf ...[more]