Ontology highlight
ABSTRACT:
SUBMITTER: Caballero-Franco C
PROVIDER: S-EPMC4761524 | biostudies-literature | 2016 Mar
REPOSITORIES: biostudies-literature
Caballero-Franco Celia C Guma Monica M Choo Min-Kyung MK Sano Yasuyo Y Enzler Thomas T Enzler Thomas T Karin Michael M Mizoguchi Atsushi A Park Jin Mo JM
Journal of immunology (Baltimore, Md. : 1950) 20160120 5
The protein kinase p38α mediates cellular responses to environmental and endogenous cues that direct tissue homeostasis and immune responses. Studies of mice lacking p38α in several different cell types have demonstrated that p38α signaling is essential to maintaining the proliferation-differentiation balance in developing and steady-state tissues. The mechanisms underlying these roles involve cell-autonomous control of signaling and gene expression by p38α. In this study, we show that p38α regu ...[more]