Ontology highlight
ABSTRACT:
SUBMITTER: Ji H
PROVIDER: S-EPMC4763719 | biostudies-literature | 2016 Apr
REPOSITORIES: biostudies-literature
Biomaterials 20160203
Access to smooth muscle cells (SMC) would create opportunities for tissue engineering, drug testing, and disease modeling. Herein we report the direct conversion of human endothelial progenitor cells (EPC) to induced smooth muscle cells (iSMC) by induced expression of MYOCD. The EPC undergo a cytoskeletal rearrangement resembling that of mesenchymal cells within 3 days post initiation of MYOCD expression. By day 7, the reprogrammed cells show upregulation of smooth muscle markers ACTA2, MYH11, a ...[more]