Ontology highlight
ABSTRACT:
SUBMITTER: Zheng JH
PROVIDER: S-EPMC4764437 | biostudies-literature | 2016 Apr
REPOSITORIES: biostudies-literature
Zheng Jia-Hua JH Rower Caitlin C McAllister Kevin K Castillo-Mancilla Jose J Klein Brandon B Meditz Amie A Guida L Anthony LA Kiser Jennifer J JJ Bushman Lane R LR Anderson Peter L PL
Journal of pharmaceutical and biomedical analysis 20160121
This communication describes the application of an existing intracellular methodology to the quantitation of tenofovir-diphosphate (TFV-DP) and emtricitabine-triphosphate (FTC-TP) from erythrocytes using dried blood spots (DBS). Concentrations were determined from a 3mm DBS punch extracted into a 70:30 methanol:water solution (lysed cellular matrix). This extraction solution was then subjected to a previously validated analytical procedure for lysed cellular matrix. Experiments for DBS validatio ...[more]