Ontology highlight
ABSTRACT:
SUBMITTER: Su T
PROVIDER: S-EPMC4766439 | biostudies-literature | 2016 Feb
REPOSITORIES: biostudies-literature
Scientific reports 20160225
Recently, phosphodiesterase-9 (PDE9) inhibitors and biometal-chelators have received much attention as potential therapeutics for the treatment of Alzheimer's disease (AD). Here, we designed, synthesized, and evaluated a novel series of PDE9 inhibitors with the ability to chelate metal ions. The bioassay results showed that most of these molecules strongly inhibited PDE9 activity. Compound 16 showed an IC50 of 34 nM against PDE9 and more than 55-fold selectivity against other PDEs. In addition, ...[more]