Ontology highlight
ABSTRACT:
SUBMITTER: Krol S
PROVIDER: S-EPMC8340127 | biostudies-literature | 2021 Aug
REPOSITORIES: biostudies-literature
Król Sylwia S Österlund Nicklas N Vosough Faraz F Jarvet Jüri J Wärmländer Sebastian S Barth Andreas A Ilag Leopold L LL Magzoub Mazin M Gräslund Astrid A Mörman Cecilia C
iScience 20210710 8
Substantial research efforts have gone into elucidating the role of protein misfolding and self-assembly in the onset and progression of Alzheimer's disease (AD). Aggregation of the Amyloid-β (Aβ) peptide into insoluble fibrils is closely associated with AD. Here, we use biophysical techniques to study a peptide-based approach to target Aβ amyloid aggregation. A peptide construct, NCAM-PrP, consists of a largely hydrophobic signal sequence linked to a positively charged hexapeptide. The NCAM-PrP ...[more]