Ontology highlight
ABSTRACT:
SUBMITTER: Lerner TR
PROVIDER: S-EPMC4767353 | biostudies-literature | 2016 Mar
REPOSITORIES: biostudies-literature
The Journal of clinical investigation 20160222 3
In extrapulmonary tuberculosis, the most common site of infection is within the lymphatic system, and there is growing recognition that lymphatic endothelial cells (LECs) are involved in immune function. Here, we identified LECs, which line the lymphatic vessels, as a niche for Mycobacterium tuberculosis in the lymph nodes of patients with tuberculosis. In cultured primary human LECs (hLECs), we determined that M. tuberculosis replicates both in the cytosol and within autophagosomes, but the bac ...[more]