Ontology highlight
ABSTRACT:
SUBMITTER: Mondor I
PROVIDER: S-EPMC6697131 | biostudies-literature | 2019 Jun
REPOSITORIES: biostudies-literature
Mondor Isabelle I Baratin Myriam M Lagueyrie Marine M Saro Lisa L Henri Sandrine S Gentek Rebecca R Suerinck Delphine D Kastenmuller Wolfgang W Jiang Jean X JX Bajénoff Marc M
Immunity 20190430 6
In lymph nodes, subcapsular sinus macrophages (SSMs) form an immunological barrier that monitors lymph drained from peripheral tissues. Upon infection, SSMs activate B and natural killer T (NKT) cells while secreting inflammatory mediators. Here, we investigated the mechanisms regulating development and homeostasis of SSMs. Embryonic SSMs originated from yolk sac hematopoiesis and were replaced by a postnatal wave of bone marrow (BM)-derived monocytes that proliferated to establish the adult SSM ...[more]