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Significant impact of miRNA-target gene networks on genetics of human complex traits.


ABSTRACT: The impact of microRNA (miRNA) on the genetics of human complex traits, especially in the context of miRNA-target gene networks, has not been fully assessed. Here, we developed a novel analytical method, MIGWAS, to comprehensively evaluate enrichment of genome-wide association study (GWAS) signals in miRNA-target gene networks. We applied the method to the GWAS results of the 18 human complex traits from >1.75 million subjects, and identified significant enrichment in rheumatoid arthritis (RA), kidney function, and adult height (P?

SUBMITTER: Okada Y 

PROVIDER: S-EPMC4772006 | biostudies-literature | 2016 Mar

REPOSITORIES: biostudies-literature

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Significant impact of miRNA-target gene networks on genetics of human complex traits.

Okada Yukinori Y   Muramatsu Tomoki T   Suita Naomasa N   Kanai Masahiro M   Kawakami Eiryo E   Iotchkova Valentina V   Soranzo Nicole N   Inazawa Johji J   Tanaka Toshihiro T  

Scientific reports 20160301


The impact of microRNA (miRNA) on the genetics of human complex traits, especially in the context of miRNA-target gene networks, has not been fully assessed. Here, we developed a novel analytical method, MIGWAS, to comprehensively evaluate enrichment of genome-wide association study (GWAS) signals in miRNA-target gene networks. We applied the method to the GWAS results of the 18 human complex traits from >1.75 million subjects, and identified significant enrichment in rheumatoid arthritis (RA),  ...[more]

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