Significant impact of miRNA-target gene networks on genetics of human complex traits.
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ABSTRACT:
SUBMITTER: Okada Y
PROVIDER: S-EPMC4772006 | biostudies-literature | 2016 Mar
REPOSITORIES: biostudies-literature
Publications
Significant impact of miRNA-target gene networks on genetics of human complex traits.
Okada Yukinori Y Muramatsu Tomoki T Suita Naomasa N Kanai Masahiro M Kawakami Eiryo E Iotchkova Valentina V Soranzo Nicole N Inazawa Johji J Tanaka Toshihiro T
Scientific reports 20160301
The impact of microRNA (miRNA) on the genetics of human complex traits, especially in the context of miRNA-target gene networks, has not been fully assessed. Here, we developed a novel analytical method, MIGWAS, to comprehensively evaluate enrichment of genome-wide association study (GWAS) signals in miRNA-target gene networks. We applied the method to the GWAS results of the 18 human complex traits from >1.75 million subjects, and identified significant enrichment in rheumatoid arthritis (RA), ...[more]
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