Calcium imaging of sleep-wake related neuronal activity in the dorsal pons.
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ABSTRACT:
SUBMITTER: Cox J
PROVIDER: S-EPMC4773416 | biostudies-literature | 2016 Feb
REPOSITORIES: biostudies-literature
Publications
Calcium imaging of sleep-wake related neuronal activity in the dorsal pons.
Cox Julia J Pinto Lucas L Dan Yang Y
Nature communications 20160225
The dorsal pons has long been implicated in the generation of rapid eye movement (REM) sleep, but the underlying circuit mechanisms remain poorly understood. Using cell-type-specific microendoscopic Ca(2+) imaging in and near the laterodorsal tegmental nucleus, we found that many glutamatergic neurons are maximally active during REM sleep (REM-max), while the majority of GABAergic neurons are maximally active during wakefulness (wake-max). Furthermore, the activity of glutamatergic neurons exhib ...[more]
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