Ontology highlight
ABSTRACT:
SUBMITTER: Hengen KB
PROVIDER: S-EPMC4809041 | biostudies-literature | 2016 Mar
REPOSITORIES: biostudies-literature
Hengen Keith B KB Torrado Pacheco Alejandro A McGregor James N JN Van Hooser Stephen D SD Turrigiano Gina G GG
Cell 20160317 1
Homeostatic mechanisms stabilize neural circuit function by keeping firing rates within a set-point range, but whether this process is gated by brain state is unknown. Here, we monitored firing rate homeostasis in individual visual cortical neurons in freely behaving rats as they cycled between sleep and wake states. When neuronal firing rates were perturbed by visual deprivation, they gradually returned to a precise, cell-autonomous set point during periods of active wake, with lengthening of t ...[more]