Ontology highlight
ABSTRACT:
SUBMITTER: Biddle A
PROVIDER: S-EPMC4776071 | biostudies-literature | 2016 Feb
REPOSITORIES: biostudies-literature
Biddle Adrian A Gammon Luke L Liang Xiao X Costea Daniela Elena DE Mackenzie Ian C IC
EBioMedicine 20160109
Cancer stem cells (CSCs) drive tumour spread and therapeutic resistance, and can undergo epithelial-to-mesenchymal transition (EMT) and mesenchymal-to-epithelial transition (MET) to switch between epithelial and post-EMT sub-populations. Examining oral squamous cell carcinoma (OSCC), we now show that increased phenotypic plasticity, the ability to undergo EMT/MET, underlies increased CSC therapeutic resistance within both the epithelial and post-EMT sub-populations. The post-EMT CSCs that posses ...[more]