Ontology highlight
ABSTRACT:
SUBMITTER: Wang L
PROVIDER: S-EPMC4776143 | biostudies-literature | 2016 Mar
REPOSITORIES: biostudies-literature
Wang Lihui L Li Xirui X Huang Wenhao W Zhou Tiancheng T Wang Haitao H Lin Aiping A Hutchins Andrew Paul AP Su Zhenghui Z Chen Qianyu Q Pei Duanqing D Pan Guangjin G
Scientific reports 20160303
Human urine cells (HUCs) can be reprogrammed into neural progenitor cells (NPCs) or induced pluripotent stem cells (iPSCs) with defined factors and a small molecule cocktail, but the underlying fate choice remains unresolved. Here, through sequential removal of individual compound from small molecule cocktail, we showed that A8301, a TGFβ signaling inhibitor, is sufficient to switch the cell fate from iPSCs into NPCs in OSKM-mediated HUCs reprogramming. However, TGFβ exposure at early stage inhi ...[more]