Ontology highlight
ABSTRACT:
SUBMITTER: Jiang J
PROVIDER: S-EPMC6320693 | biostudies-literature | 2017 Nov
REPOSITORIES: biostudies-literature
Jiang Jiansheng J Natarajan Kannan K Boyd Lisa F LF Morozov Giora I GI Mage Michael G MG Margulies David H DH
Science (New York, N.Y.) 20171012 6366
Central to CD8<sup>+</sup> T cell-mediated immunity is the recognition of peptide-major histocompatibility complex class I (p-MHC I) proteins displayed by antigen-presenting cells. Chaperone-mediated loading of high-affinity peptides onto MHC I is a key step in the MHC I antigen presentation pathway. However, the structure of MHC I with a chaperone that facilitates peptide loading has not been determined. We report the crystal structure of MHC I in complex with the peptide editor TAPBPR (TAP-bin ...[more]