Ontology highlight
ABSTRACT:
SUBMITTER: Fraietta JA
PROVIDER: S-EPMC4778162 | biostudies-literature | 2016 Mar
REPOSITORIES: biostudies-literature
Fraietta Joseph A JA Beckwith Kyle A KA Patel Prachi R PR Ruella Marco M Zheng Zhaohui Z Barrett David M DM Lacey Simon F SF Melenhorst Jan Joseph JJ McGettigan Shannon E SE Cook Danielle R DR Zhang Changfeng C Xu Jun J Do Priscilla P Hulitt Jessica J Kudchodkar Sagar B SB Cogdill Alexandria P AP Gill Saar S Porter David L DL Woyach Jennifer A JA Long Meixiao M Johnson Amy J AJ Maddocks Kami K Muthusamy Natarajan N Levine Bruce L BL June Carl H CH Byrd John C JC Maus Marcela V MV
Blood 20160126 9
Anti-CD19 chimeric antigen receptor (CAR) T-cell therapy is highly promising but requires robust T-cell expansion and engraftment. A T-cell defect in chronic lymphocytic leukemia (CLL) due to disease and/or therapy impairs ex vivo expansion and response to CAR T cells. To evaluate the effect of ibrutinib treatment on the T-cell compartment in CLL as it relates to CAR T-cell generation, we examined the phenotype and function of T cells in a cohort of CLL patients during their course of treatment ...[more]