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Enhancing Chimeric Antigen Receptor T-Cell Efficacy in Solid Tumors.

ABSTRACT: Chimeric antigen receptor (CAR) T-cell therapy has been acclaimed as a revolution in cancer treatment following the impressive results in hematologic malignancies. Unfortunately, in patients with solid tumors, objectives responses to CAR T cells are still anecdotal, and important issues are driven by on-target but off-tumor activity of CAR T cells and by the extremely complex biology of solid tumors. Here, we will review the recent attempts to challenge the therapeutic impediments to CAR T-cell therapy in solid tumors. We will focus on the most promising strategies of antigen targeting to improve tumor specificity and address the tumor heterogeneity, efforts to circumvent the physical barriers of the tumor architecture such as subverted tumor vasculature, impediments of CAR T-cell trafficking and immune suppressive microenvironment.

SUBMITTER: Fuca G

PROVIDER: S-EPMC7269829 | biostudies-literature | 2020 Jun

REPOSITORIES: biostudies-literature

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Enhancing Chimeric Antigen Receptor T-Cell Efficacy in Solid Tumors.

Fucà Giovanni G Reppel Loic L Landoni Elisa E Savoldo Barbara B Dotti Gianpietro G

Clinical cancer research : an official journal of the American Association for Cancer Research 20200203 11

Chimeric antigen receptor (CAR) T-cell therapy has been acclaimed as a revolution in cancer treatment following the impressive results in hematologic malignancies. Unfortunately, in patients with solid tumors, objectives responses to CAR T cells are still anecdotal, and important issues are driven by on-target but off-tumor activity of CAR T cells and by the extremely complex biology of solid tumors. Here, we will review the recent attempts to challenge the therapeutic impediments to CAR T-cell ...[more]

PMID: 32015021

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