Ontology highlight
ABSTRACT:
SUBMITTER: Park CM
PROVIDER: S-EPMC4782721 | biostudies-literature | 2016 Mar
REPOSITORIES: biostudies-literature
Park Chung-Min CM Johnson Brett A BA Duan Jicheng J Park Jeong-Jin JJ Day Jacob J JJ Gang David D Qian Wei-Jun WJ Xian Ming M
Organic letters 20160212 5
The development of a functional disulfide, FmSSPy-A (Fm = 9-fluorenylmethyl; Py = pyridinyl), is reported. It can effectively convert small molecule and protein thiols (-SH) to form -S-SFm adducts under mild conditions. This method allows for a H2S-free and biomimetic protocol to generate highly reactive persulfides (in their anionic forms). The high nucleophilicity of persulfides toward a number of thiol-blocking reagents is also demonstrated. The method holds promise for further understanding ...[more]