Ontology highlight
ABSTRACT:
SUBMITTER: Palanca-Wessels MC
PROVIDER: S-EPMC4891060 | biostudies-literature | 2016 Feb
REPOSITORIES: biostudies-literature
Palanca-Wessels Maria C MC Booth Garrett C GC Convertine Anthony J AJ Lundy Brittany B BB Berguig Geoffrey Y GY Press Michael F MF Stayton Patrick S PS Press Oliver W OW
Oncotarget 20160201 8
The therapeutic potential of RNA interference (RNAi) has been limited by inefficient delivery of short interfering RNA (siRNA). Tumor-specific recognition can be effectively achieved by antibodies directed against highly expressed cancer cell surface receptors. We investigated the utility of linking an internalizing streptavidin-conjugated HER2 antibody to an endosome-disruptive biotinylated polymeric nanocarrier to improve the functional cytoplasmic delivery of siRNA in breast and ovarian cance ...[more]