Ontology highlight
ABSTRACT:
SUBMITTER: Vajdos FF
PROVIDER: S-EPMC2143596 | biostudies-other | 1997 Nov
REPOSITORIES: biostudies-other
Vajdos F F FF Yoo S S Houseweart M M Sundquist W I WI Hill C P CP
Protein science : a publication of the Protein Society 19971101 11
The cellular protein, cyclophilin A (CypA), is incorporated into the virion of the type 1 human immunodeficiency virus (HIV-1) via a direct interaction with the capsid domain of the viral Gag polyprotein. We demonstrate that the capsid sequence 87His-Ala-Gly-Pro-Ile-Ala92 (87HAGPIA92) encompasses the primary cyclophilin A binding site and present an X-ray crystal structure of the CypA/HAGPIA complex. In contrast to the cis prolines observed in all previously reported structures of CypA complexed ...[more]