Ontology highlight
ABSTRACT:
SUBMITTER: Weigel C
PROVIDER: S-EPMC4792958 | biostudies-literature | 2016 Mar
REPOSITORIES: biostudies-literature
Weigel Christoph C Veldwijk Marlon R MR Oakes Christopher C CC Seibold Petra P Slynko Alla A Liesenfeld David B DB Rabionet Mariona M Hanke Sabrina A SA Wenz Frederik F Sperk Elena E Benner Axel A Rösli Christoph C Sandhoff Roger R Assenov Yassen Y Plass Christoph C Herskind Carsten C Chang-Claude Jenny J Schmezer Peter P Popanda Odilia O
Nature communications 20160311
Radiotherapy is a fundamental part of cancer treatment but its use is limited by the onset of late adverse effects in the normal tissue, especially radiation-induced fibrosis. Since the molecular causes for fibrosis are largely unknown, we analyse if epigenetic regulation might explain inter-individual differences in fibrosis risk. DNA methylation profiling of dermal fibroblasts obtained from breast cancer patients prior to irradiation identifies differences associated with fibrosis. One region ...[more]