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A specific role for PRND in goat foetal Leydig cells is suggested by prion family gene expression during gonad development in goats and mice.

ABSTRACT: Three genes of the prion protein gene family are expressed in gonads. Comparative analyses of their expression patterns in mice and goats revealed constant expression of PRNP and SPRN in both species and in both male and female gonads, but with a weaker expression of SPRN. By contrast, expression of PRND was found to be sex-dimorphic, in agreement with its role in spermatogenesis. More importantly, our study revealed that PRND seems to be a key marker of foetal Leydig cells specifically in goats, suggesting a yet unknown role for its encoded protein Doppel during gonadal differentiation in nonrodent mammals.

SUBMITTER: Allais-Bonnet A

PROVIDER: S-EPMC4794797 | biostudies-literature | 2016 Jan

REPOSITORIES: biostudies-literature

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A specific role for PRND in goat foetal Leydig cells is suggested by prion family gene expression during gonad development in goats and mice.

Allais-Bonnet Aurélie A Castille Johan J Pannetier Maëlle M Passet Bruno B Elzaïat Maëva M André Marjolaine M Montazer-Torbati Fatemeh F Moazami-Goudarzi Katayoun K Vilotte Jean-Luc JL Pailhoux Eric E

FEBS open bio 20160114 1

Three genes of the prion protein gene family are expressed in gonads. Comparative analyses of their expression patterns in mice and goats revealed constant expression of PRNP and SPRN in both species and in both male and female gonads, but with a weaker expression of SPRN. By contrast, expression of PRND was found to be sex-dimorphic, in agreement with its role in spermatogenesis. More importantly, our study revealed that PRND seems to be a key marker of foetal Leydig cells specifically in goats ...[more]

PMID: 27047737

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Prion-like protein gene (PRND) polymorphisms associated with scrapie susceptibility in Korean native black goats.

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| S-EPMC3688755 | biostudies-literature

Rainfall-driven sex-ratio genes in African buffalo suggested by correlations between Y-chromosomal haplotype frequencies and foetal sex ratio.

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| S-EPMC2875233 | biostudies-literature

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