Ontology highlight
ABSTRACT:
SUBMITTER: Lake RJ
PROVIDER: S-EPMC4797267 | biostudies-literature | 2016 Mar
REPOSITORIES: biostudies-literature
Lake Robert J RJ Boetefuer Erica L EL Won Kyoung-Jae KJ Fan Hua-Ying HY
Nucleic acids research 20151117 5
Cockayne syndrome is a premature aging disease associated with numerous developmental and neurological abnormalities, and elevated levels of reactive oxygen species have been found in cells derived from Cockayne syndrome patients. The majority of Cockayne syndrome cases contain mutations in the ATP-dependent chromatin remodeler CSB; however, how CSB protects cells from oxidative stress remains largely unclear. Here, we demonstrate that oxidative stress alters the genomic occupancy of the CSB pro ...[more]