Ontology highlight
ABSTRACT:
SUBMITTER: Batenburg NL
PROVIDER: S-EPMC5715124 | biostudies-literature | 2017 Dec
REPOSITORIES: biostudies-literature
Batenburg Nicole L NL Walker John R JR Noordermeer Sylvie M SM Moatti Nathalie N Durocher Daniel D Zhu Xu-Dong XD
Nature communications 20171204 1
CSB, a member of the SWI2/SNF2 superfamily, is implicated in DNA double-strand break (DSB) repair. However, how it regulates this repair process is poorly understood. Here we uncover that CSB interacts via its newly identified winged helix domain with RIF1, an effector of 53BP1, and that this interaction mediates CSB recruitment to DSBs in S phase. At DSBs, CSB remodels chromatin by evicting histones, which limits RIF1 and its effector MAD2L2 but promotes BRCA1 accumulation. The chromatin remode ...[more]