Iron-catalyzed Cross-Coupling of Propargyl Carboxylates and Grignard Reagents: Synthesis of Substituted Allenes.

ABSTRACT: Presented herein is a mild, facile, and efficient iron-catalyzed synthesis of substituted allenes from propargyl carboxylates and Grignard reagents. Only 1-5?mol?% of the inexpensive and environmentally benign [Fe(acac)3 ] at -20?°C was sufficient to afford a broad range of substituted allenes in excellent yields. The method tolerates a variety of functional groups.

SUBMITTER: Kessler SN 

PROVIDER: S-EPMC4797716 | biostudies-literature | 2016 Mar

REPOSITORIES: biostudies-literature