Ontology highlight
ABSTRACT:
SUBMITTER: Chandran K
PROVIDER: S-EPMC4797943 | biostudies-literature | 2005 Jun
REPOSITORIES: biostudies-literature
Chandran Kartik K Sullivan Nancy J NJ Felbor Ute U Whelan Sean P SP Cunningham James M JM
Science (New York, N.Y.) 20050414 5728
Ebola virus (EboV) causes rapidly fatal hemorrhagic fever in humans and there is currently no effective treatment. We found that the infection of African green monkey kidney (Vero) cells by vesicular stomatitis viruses bearing the EboV glycoprotein (GP) requires the activity of endosomal cysteine proteases. Using selective protease inhibitors and protease-deficient cell lines, we identified an essential role for cathepsin B (CatB) and an accessory role for cathepsin L (CatL) in EboV GP-dependent ...[more]