Ontology highlight
ABSTRACT:
SUBMITTER: Williams KM
PROVIDER: S-EPMC4801753 | biostudies-literature | 2016 Apr
REPOSITORIES: biostudies-literature
Williams Kirsten M KM Cheng Guang-Shing GS Pusic Iskra I Jagasia Madan M Burns Linda L Ho Vincent T VT Pidala Joseph J Palmer Jeanne J Johnston Laura L Mayer Sebastian S Chien Jason W JW Jacobsohn David A DA Pavletic Steven Z SZ Martin Paul J PJ Storer Barry E BE Inamoto Yoshihiro Y Chai Xiaoyu X Flowers Mary E D MED Lee Stephanie J SJ
Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation 20151022 4
Bronchiolitis obliterans syndrome (BOS) after allogeneic hematopoietic cell transplantation (HCT) is associated with high mortality. We hypothesized that inhaled fluticasone, azithromycin, and montelukast (FAM) with a brief steroid pulse could avert progression of new-onset BOS. We tested this in a phase II, single-arm, open-label, multicenter study (NCT01307462). Thirty-six patients were enrolled within 6 months of BOS diagnosis. The primary endpoint was treatment failure, defined as 10% or gre ...[more]