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How I treat bronchiolitis obliterans syndrome after hematopoietic stem cell transplantation.


ABSTRACT: In past years, a diagnosis of bronchiolitis obliterans syndrome (BOS) after allogeneic hematopoietic cell transplant (HCT) conferred nearly universal mortality secondary to lack of consensus for diagnostic criteria, poorly understood disease pathogenesis, and very few studies of therapeutic or supportive care interventions. Recently, however, progress has been made in these areas: revised consensus diagnostic guidelines are now available, supportive care has improved, there is greater understanding of potential mechanisms of disease, and prospective trials are being conducted. This article describes these advances and provides suggestions to optimize therapy for patients with BOS after HCT.

SUBMITTER: Williams KM 

PROVIDER: S-EPMC5270387 | biostudies-literature | 2017 Jan

REPOSITORIES: biostudies-literature

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How I treat bronchiolitis obliterans syndrome after hematopoietic stem cell transplantation.

Williams Kirsten M KM  

Blood 20161116 4


In past years, a diagnosis of bronchiolitis obliterans syndrome (BOS) after allogeneic hematopoietic cell transplant (HCT) conferred nearly universal mortality secondary to lack of consensus for diagnostic criteria, poorly understood disease pathogenesis, and very few studies of therapeutic or supportive care interventions. Recently, however, progress has been made in these areas: revised consensus diagnostic guidelines are now available, supportive care has improved, there is greater understand  ...[more]

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