Ontology highlight
ABSTRACT:
SUBMITTER: Nakamura S
PROVIDER: S-EPMC4804169 | biostudies-literature | 2016
REPOSITORIES: biostudies-literature
Nakamura Shuhei S Karalay Özlem Ö Jäger Philipp S PS Horikawa Makoto M Klein Corinna C Nakamura Kayo K Latza Christian C Templer Sven E SE Dieterich Christoph C Antebi Adam A
Nature communications 20160322
Germline removal provokes longevity in several species and shifts resources towards survival and repair. Several Caenorhabditis elegans transcription factors regulate longevity arising from germline removal; yet, how they work together is unknown. Here we identify a Myc-like HLH transcription factor network comprised of Mondo/Max-like complex (MML-1/MXL-2) to be required for longevity induced by germline removal, as well as by reduced TOR, insulin/IGF signalling and mitochondrial function. Germl ...[more]