Ontology highlight
ABSTRACT:
SUBMITTER: Yu F
PROVIDER: S-EPMC4807984 | biostudies-literature | 2016 Jan
REPOSITORIES: biostudies-literature
Yu Fujun F Lu Zhongqiu Z Huang Kate K Wang Xiaodong X Xu Ziqiang Z Chen Bicheng B Dong Peihong P Zheng Jianjian J
Oncotarget 20160101 1
Aberrant Wnt/β-catenin pathway contributes to the development of liver fibrosis. MicroRNAs (MiRNAs) are found to act as regulators of the activation of hepatic stellate cell (HSC) in liver fibrosis. However, whether miRNAs activate Wnt/β-catenin pathway in activated HSCs during liver fibrosis is largely unknown. In this study, we found that Salvianolic acid B (Sal B) treatment significantly inhibited liver fibrosis in CCl4-treated rats, HSC-T6 cells and rat primary HSCs, resulting in the suppres ...[more]