Ontology highlight
ABSTRACT:
SUBMITTER: Yang Z
PROVIDER: S-EPMC8564337 | biostudies-literature | 2021 Nov
REPOSITORIES: biostudies-literature
Yang Zhuoli Z Liu Hua H Song Ran R Lu Wenxiu W Wang Haibo H Gu Siyu S Cao Xuedi X Chen Yibin Y Liang Jihuan J Qin Qiong Q Yang Xiaomei X Feng Duiping D He Junqi J
FEBS open bio 20211001 11
Human papillomavirus type 18 (HPV18) has high carcinogenic power in invasive cervical cancer (ICC) development. However, the underlying mechanism remains elusive. The carcinogenic properties of HPV18 require the PDZ-binding motif of its E6 oncoprotein (HPV18 E6) to degrade its target PSD95/Dlg/ZO-1 (PDZ) proteins. In this study, we demonstrated that the PDZ protein membrane-associated guanylate kinase, WW and PDZ domain containing 3 (MAGI3) inhibited the Wnt/β-catenin pathway, and subsequently c ...[more]