Ontology highlight
ABSTRACT:
SUBMITTER: Hamm ML
PROVIDER: S-EPMC4808366 | biostudies-literature | 2016 Apr
REPOSITORIES: biostudies-literature
Hamm Michelle L ML McFadden Emily J EJ Ghio Michael M Lindell Maria A M MA Gerien Kenneth S KS O'Handley Suzanne F SF
Bioorganic & medicinal chemistry letters 20160302 8
The bacterial repair enzyme MutT hydrolyzes the damaged nucleotide OdGTP (the 5'-triphosphate derivative of 8-oxo-2'-deoxyguanosine; OdG), which is a known mutagen and has been linked to antibacterial action. Previous work has indicated important roles for the C8-oxygen, N7-hydrogen, and C2-exocyclic amine during OdGTP recognition by MutT. In order to gain a more nuanced understanding of the contribution of these three sites to the overall activity of MutT, we determined the reaction parameters ...[more]