Ontology highlight
ABSTRACT:
SUBMITTER: Adamson SE
PROVIDER: S-EPMC4811113 | biostudies-literature | 2016 Apr
REPOSITORIES: biostudies-literature
Adamson Samantha E SE Griffiths Rachael R Moravec Radim R Senthivinayagam Subramanian S Montgomery Garren G Chen Wenshu W Han Jenny J Sharma Poonam R PR Mullins Garrett R GR Gorski Stacey A SA Cooper Jonathan A JA Kadl Alexandra A Enfield Kyle K Braciale Thomas J TJ Harris Thurl E TE Leitinger Norbert N
The Journal of clinical investigation 20160229 4
Acute and chronic tissue injury results in the generation of a myriad of environmental cues that macrophages respond to by changing their phenotype and function. This phenotypic regulation is critical for controlling tissue inflammation and resolution. Here, we have identified the adaptor protein disabled homolog 2 (DAB2) as a regulator of phenotypic switching in macrophages. Dab2 expression was upregulated in M2 macrophages and suppressed in M1 macrophages isolated from both mice and humans, an ...[more]