Ontology highlight
ABSTRACT:
SUBMITTER: Nonaka T
PROVIDER: S-EPMC4811119 | biostudies-literature | 2016 Apr
REPOSITORIES: biostudies-literature
Nonaka Taichiro T Toda Yoshinobu Y Hiai Hiroshi H Uemura Munehiro M Nakamura Motonobu M Yamamoto Norio N Asato Ryo R Hattori Yukari Y Bessho Kazuhisa K Minato Nagahiro N Kinoshita Kazuo K
The Journal of clinical investigation 20160314 4
Most skin cancers develop as the result of UV light-induced DNA damage; however, a substantial number of cases appear to occur independently of UV damage. A causal link between UV-independent skin cancers and chronic inflammation has been suspected, although the precise mechanism underlying this association is unclear. Here, we have proposed that activation-induced cytidine deaminase (AID, encoded by AICDA) links chronic inflammation and skin cancer. We demonstrated that Tg mice expressing AID i ...[more]