Ontology highlight
ABSTRACT:
SUBMITTER: Clapham HE
PROVIDER: S-EPMC4813744 | biostudies-literature | 2016 May
REPOSITORIES: biostudies-literature
Clapham Hannah E HE Rodriguez-Barraquer Isabel I Azman Andrew S AS Althouse Benjamin M BM Salje Henrik H Gibbons Robert V RV Rothman Alan L AL Jarman Richard G RG Nisalak Ananda A Thaisomboonsuk Butsaya B Kalayanarooj Siripen S Nimmannitya Suchitra S Vaughn David W DW Green Sharone S Yoon In-Kyu IK Cummings Derek A T DA
The Journal of infectious diseases 20151223 9
The immune response to dengue virus (DENV) infection is complex and not fully understood. Using longitudinal data from 181 children with dengue in Thailand who were followed for up to 3 years, we describe neutralizing antibody kinetics following symptomatic DENV infection. We observed that antibody titers varied by serotype, homotypic vs heterotypic responses, and primary versus postprimary infections. The rates of change in antibody titers over time varied between primary and postprimary respon ...[more]