Ontology highlight
ABSTRACT:
SUBMITTER: McNamara DE
PROVIDER: S-EPMC6126679 | biostudies-literature | 2018 Aug
REPOSITORIES: biostudies-literature
McNamara Dan E DE Quarato Giovanni G Guy Cliff S CS Green Douglas R DR Moldoveanu Tudor T
Journal of visualized experiments : JoVE 20180807 138
Necroptosis is a programmed cell death pathway triggered by activation of receptor interacting protein kinase 3 (RIPK3), which phosphorylates and activates the mixed lineage kinase-like domain pseudokinase, MLKL, to rupture or permeabilize the plasma membrane. Necroptosis is an inflammatory pathway associated with multiple pathologies including autoimmunity, infectious and cardiovascular diseases, stroke, neurodegeneration, and cancer. Here, we describe protocols that can be used to characterize ...[more]