Ontology highlight
ABSTRACT:
SUBMITTER: Li HL
PROVIDER: S-EPMC4816169 | biostudies-literature | 2016 Jan
REPOSITORIES: biostudies-literature
Li H-L HL Wei J-F JF Fan L-Y LY Wang S-H SH Zhu L L Li T-P TP Lin G G Sun Y Y Sun Z-J ZJ Ding J J Liang X-L XL Li J J Han Q Q Zhao R-C-H RC
Cell death & disease 20160128
Pluripotency makes human pluripotent stem cells (hPSCs) promising for regenerative medicine, but the teratoma formation has been considered to be a major obstacle for their clinical applications. Here, we determined that the downregulation of miR-302 suppresses the teratoma formation, hampers the self-renewal and pluripotency, and promotes hPSC differentiation. The underlying mechanism is that the high endogenous expression of miR-302 suppresses the AKT1 expression by directly targeting its 3'UT ...[more]