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?-C(sp(3))-H Arylation of ?-Hydroxy Acid Derivatives Utilizing Amino Acid as a Directing Group.

ABSTRACT: The Pd(II)-catalyzed arylation of unactivated ?-C(sp(3))-H bonds in ?-hydroxy aliphatic acid with a variety of aryl iodides was developed utilizing an amino acid auxiliary as a directing group. This protocol provides access to biologically active ?-arylated-?-hydroxy acid derivatives.

SUBMITTER: Toba T

PROVIDER: S-EPMC4817547 | biostudies-literature | 2015 Dec

REPOSITORIES: biostudies-literature

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β-C(sp(3))-H Arylation of α-Hydroxy Acid Derivatives Utilizing Amino Acid as a Directing Group.

Toba Tetsuya T Hu Yi Y Tran Anh T AT Yu Jin-Quan JQ

Organic letters 20151204 24

The Pd(II)-catalyzed arylation of unactivated β-C(sp(3))-H bonds in α-hydroxy aliphatic acid with a variety of aryl iodides was developed utilizing an amino acid auxiliary as a directing group. This protocol provides access to biologically active β-arylated-α-hydroxy acid derivatives. ...[more]

PMID: 26635188

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