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Ligand-Enabled Arylation of ?-C-H Bonds.

ABSTRACT: Pd(II) -catalyzed arylation of ?-C(sp(3) )-H bonds of aliphatic acid-derived amides was developed by using quinoline-based ligands. Various ?-aryl-?-amino acids were prepared from natural amino acids using this method. The influence of ligand structure on reactivity was also systematically investigated.

SUBMITTER: Li S

PROVIDER: S-EPMC4821162 | biostudies-literature | 2016 Mar

REPOSITORIES: biostudies-literature

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Ligand-Enabled Arylation of γ-C-H Bonds.

Li Suhua S Zhu Ru-Yi RY Xiao Kai-Jiong KJ Yu Jin-Quan JQ

Angewandte Chemie (International ed. in English) 20160225 13

Pd(II) -catalyzed arylation of γ-C(sp(3) )-H bonds of aliphatic acid-derived amides was developed by using quinoline-based ligands. Various γ-aryl-α-amino acids were prepared from natural amino acids using this method. The influence of ligand structure on reactivity was also systematically investigated. ...[more]

PMID: 26919066

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