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Ligand-Enabled Auxiliary-Free meta-C-H Arylation of Phenylacetic Acids.

ABSTRACT: The meta-C-H arylation of free phenylacetic acid was realized using 2-carbomethoxynorbornene (NBE-CO2 Me) as a transient mediator. Both the modified norbornene and the mono-protected 3-amino-2-hydroxypyridine type ligand are crucial for this auxiliary-free meta-C-H arylation reaction. A series of phenylacetic acids, including mandelic acid and phenylglycine, react smoothly with various aryl iodides to provide the meta-arylated products in high yields.

SUBMITTER: Li GC

PROVIDER: S-EPMC5535739 | biostudies-literature | 2017 Jun

REPOSITORIES: biostudies-literature

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Ligand-Enabled Auxiliary-Free meta-C-H Arylation of Phenylacetic Acids.

Li Gen-Cheng GC Wang Peng P Farmer Marcus E ME Yu Jin-Quan JQ

Angewandte Chemie (International ed. in English) 20170509 24

The meta-C-H arylation of free phenylacetic acid was realized using 2-carbomethoxynorbornene (NBE-CO<sub>2</sub> Me) as a transient mediator. Both the modified norbornene and the mono-protected 3-amino-2-hydroxypyridine type ligand are crucial for this auxiliary-free meta-C-H arylation reaction. A series of phenylacetic acids, including mandelic acid and phenylglycine, react smoothly with various aryl iodides to provide the meta-arylated products in high yields. ...[more]

PMID: 28485900

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