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Ligand-Promoted Borylation of C(sp(3))-H Bonds with Palladium(II) Catalysts.

ABSTRACT: A quinoline-based ligand effectively promotes the palladium-catalyzed borylation of C(sp(3))-H bonds. Primary ?-C(sp(3))-H bonds in carboxylic acid derivatives as well as secondary C(sp(3))-H bonds in a variety of carbocyclic rings, including cyclopropanes, cyclobutanes, cyclopentanes, cyclohexanes, and cycloheptanes, can thus be borylated. This directed borylation method complements existing iridium(I)- and rhodium(I)-catalyzed C-H borylation reactions in terms of scope and operational conditions.

SUBMITTER: He J

PROVIDER: S-EPMC4821169 | biostudies-literature | 2016 Jan

REPOSITORIES: biostudies-literature

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Ligand-Promoted Borylation of C(sp(3))-H Bonds with Palladium(II) Catalysts.

He Jian J Jiang Heng H Takise Ryosuke R Zhu Ru-Yi RY Chen Gang G Dai Hui-Xiong HX Dhar T G Murali TG Shi Jun J Zhang Hao H Cheng Peter T W PT Yu Jin-Quan JQ

Angewandte Chemie (International ed. in English) 20151127 2

A quinoline-based ligand effectively promotes the palladium-catalyzed borylation of C(sp(3))-H bonds. Primary β-C(sp(3))-H bonds in carboxylic acid derivatives as well as secondary C(sp(3))-H bonds in a variety of carbocyclic rings, including cyclopropanes, cyclobutanes, cyclopentanes, cyclohexanes, and cycloheptanes, can thus be borylated. This directed borylation method complements existing iridium(I)- and rhodium(I)-catalyzed C-H borylation reactions in terms of scope and operational conditio ...[more]

PMID: 26611496

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