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Ligand-Enabled Alkynylation of C(sp3 )-H Bonds with Palladium(II) Catalysts.

ABSTRACT: The palladium(II)-catalyzed ?- and ?-alkynylation of amide C(sp3 )-H bonds is enabled by pyridine-based ligands. This alkynylation reaction is compatible with substrates containing ?-tertiary or ?-quaternary carbon centers. The ?-methylene C(sp3 )-H bonds of various carbocyclic rings were also successfully alkynylated.

SUBMITTER: Fu H 

PROVIDER: S-EPMC5512278 | biostudies-literature | 2017 Feb

REPOSITORIES: biostudies-literature

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Ligand-Enabled Alkynylation of C(sp<sup>3</sup> )-H Bonds with Palladium(II) Catalysts.

Fu Haiyan H   Shen Peng-Xiang PX   He Jian J   Zhang Fanglin F   Li Suhua S   Wang Peng P   Liu Tao T   Yu Jin-Quan JQ  

Angewandte Chemie (International ed. in English) 20170112 7

The palladium(II)-catalyzed β- and γ-alkynylation of amide C(sp<sup>3</sup> )-H bonds is enabled by pyridine-based ligands. This alkynylation reaction is compatible with substrates containing α-tertiary or α-quaternary carbon centers. The β-methylene C(sp<sup>3</sup> )-H bonds of various carbocyclic rings were also successfully alkynylated. ...[more]

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