Ontology highlight
ABSTRACT:
SUBMITTER: Stepanyuk GA
PROVIDER: S-EPMC4822562 | biostudies-literature | 2016 Apr
REPOSITORIES: biostudies-literature
Stepanyuk Galina A GA Serrano Pedro P Peralta Eigen E Farr Carol L CL Axelrod Herbert L HL Geralt Michael M Das Debanu D Chiu Hsiu-Ju HJ Jaroszewski Lukasz L Deacon Ashley M AM Lesley Scott A SA Elsliger Marc-André MA Godzik Adam A Wilson Ian A IA Wüthrich Kurt K Salomon Daniel R DR Williamson James R JR
Acta crystallographica. Section D, Structural biology 20160324 Pt 4
RNA-binding protein 39 (RBM39) is a splicing factor and a transcriptional co-activator of estrogen receptors and Jun/AP-1, and its function has been associated with malignant progression in a number of cancers. The C-terminal RRM domain of RBM39 belongs to the U2AF homology motif family (UHM), which mediate protein-protein interactions through a short tryptophan-containing peptide known as the UHM-ligand motif (ULM). Here, crystal and solution NMR structures of the RBM39-UHM domain, and the crys ...[more]