Ontology highlight
ABSTRACT:
SUBMITTER: Li B
PROVIDER: S-EPMC4822990 | biostudies-literature | 2016 Apr
REPOSITORIES: biostudies-literature
Acta crystallographica. Section F, Structural biology communications 20160324 Pt 4
Telomere repeat factor 1 (TRF1) is a subunit of shelterin (also known as the telosome) and plays a critical role in inhibiting telomere elongation by telomerase. Tankyrase 1 (TNKS1) is a poly(ADP-ribose) polymerase that regulates the activity of TRF1 through poly(ADP-ribosyl)ation (PARylation). PARylation of TRF1 by TNKS1 leads to the release of TRF1 from telomeres and allows telomerase to access telomeres. The interaction between TRF1 and TNKS1 is thus important for telomere stability and the m ...[more]