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Development of a Standard Reference Material for metabolomics research.

ABSTRACT: The National Institute of Standards and Technology (NIST), in collaboration with the National Institutes of Health (NIH), has developed a Standard Reference Material (SRM) to support technology development in metabolomics research. SRM 1950 Metabolites in Human Plasma is intended to have metabolite concentrations that are representative of those found in adult human plasma. The plasma used in the preparation of SRM 1950 was collected from both male and female donors, and donor ethnicity targets were selected based upon the ethnic makeup of the U.S. population. Metabolomics research is diverse in terms of both instrumentation and scientific goals. This SRM was designed to apply broadly to the field, not toward specific applications. Therefore, concentrations of approximately 100 analytes, including amino acids, fatty acids, trace elements, vitamins, hormones, selenoproteins, clinical markers, and perfluorinated compounds (PFCs), were determined. Value assignment measurements were performed by NIST and the Centers for Disease Control and Prevention (CDC). SRM 1950 is the first reference material developed specifically for metabolomics research.

SUBMITTER: Phinney KW

PROVIDER: S-EPMC4823010 | biostudies-literature | 2013 Dec

REPOSITORIES: biostudies-literature

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Development of a Standard Reference Material for metabolomics research.

Phinney Karen W KW Ballihaut Guillaume G Bedner Mary M Benford Brandi S BS Camara Johanna E JE Christopher Steven J SJ Davis W Clay WC Dodder Nathan G NG Eppe Gauthier G Lang Brian E BE Long Stephen E SE Lowenthal Mark S MS McGaw Elizabeth A EA Murphy Karen E KE Nelson Bryant C BC Prendergast Jocelyn L JL Reiner Jessica L JL Rimmer Catherine A CA Sander Lane C LC Schantz Michele M MM Sharpless Katherine E KE Sniegoski Lorna T LT Tai Susan S-C SS Thomas Jeanice B JB Vetter Thomas W TW Welch Michael J MJ Wise Stephen A SA Wood Laura J LJ Guthrie William F WF Hagwood Charles R CR Leigh Stefan D SD Yen James H JH Zhang Nien-Fan NF Chaudhary-Webb Madhu M Chen Huiping H Fazili Zia Z LaVoie Donna J DJ McCoy Leslie F LF Momin Shahzad S SS Paladugula Neelima N Pendergrast Elizabeth C EC Pfeiffer Christine M CM Powers Carissa D CD Rabinowitz Daniel D Rybak Michael E ME Schleicher Rosemary L RL Toombs Bridgette M H BM Xu Mary M Zhang Mindy M Castle Arthur L AL

Analytical chemistry 20131203 24

The National Institute of Standards and Technology (NIST), in collaboration with the National Institutes of Health (NIH), has developed a Standard Reference Material (SRM) to support technology development in metabolomics research. SRM 1950 Metabolites in Human Plasma is intended to have metabolite concentrations that are representative of those found in adult human plasma. The plasma used in the preparation of SRM 1950 was collected from both male and female donors, and donor ethnicity targets ...[more]

PMID: 24187941

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Development of a Standard Reference Material for metabolomics research.

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Development of a Standard Reference Material for metabolomics research.

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