Ontology highlight
ABSTRACT:
SUBMITTER: Gilhooly NS
PROVIDER: S-EPMC4824097 | biostudies-literature | 2016 Apr
REPOSITORIES: biostudies-literature
Gilhooly Neville S NS Carrasco Carolina C Gollnick Benjamin B Wilkinson Martin M Wigley Dale B DB Moreno-Herrero Fernando F Dillingham Mark S MS
Nucleic acids research 20160113 6
In bacteria, the repair of double-stranded DNA breaks is modulated by Chi sequences. These are recognised by helicase-nuclease complexes that process DNA ends for homologous recombination. Chi activates recombination by changing the biochemical properties of the helicase-nuclease, transforming it from a destructive exonuclease into a recombination-promoting repair enzyme. This transition is thought to be controlled by the Chi-dependent opening of a molecular latch, which enables part of the DNA ...[more]