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Injectable and Glucose-Responsive Hydrogels Based on Boronic Acid-Glucose Complexation.

ABSTRACT: Injectable hydrogels have been widely used for a number of biomedical applications. Here, we report a new strategy to form an injectable and glucose-responsive hydrogel using the boronic acid-glucose complexation. The ratio of boronic acid and glucose functional groups is critical for hydrogel formation. In our system, polymers with 10-60% boronic acid, with the balance being glucose-modified, are favorable to form hydrogels. These hydrogels are shear-thinning and self-healing, recovering from shear-induced flow to a gel state within seconds. More importantly, these polymers displayed glucose-responsive release of an encapsulated model drug. The hydrogel reported here is an injectable and glucose-responsive hydrogel constructed from the complexation of boronic acid and glucose within a single component polymeric material.

SUBMITTER: Dong Y

PROVIDER: S-EPMC5242094 | biostudies-literature | 2016 Aug

REPOSITORIES: biostudies-literature

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Injectable and Glucose-Responsive Hydrogels Based on Boronic Acid-Glucose Complexation.

Dong Yizhou Y Wang Weiheng W Veiseh Omid O Appel Eric A EA Xue Kun K Webber Matthew J MJ Tang Benjamin C BC Yang Xi-Wen XW Weir Gordon C GC Langer Robert R Anderson Daniel G DG

Langmuir : the ACS journal of surfaces and colloids 20160817 34

Injectable hydrogels have been widely used for a number of biomedical applications. Here, we report a new strategy to form an injectable and glucose-responsive hydrogel using the boronic acid-glucose complexation. The ratio of boronic acid and glucose functional groups is critical for hydrogel formation. In our system, polymers with 10-60% boronic acid, with the balance being glucose-modified, are favorable to form hydrogels. These hydrogels are shear-thinning and self-healing, recovering from s ...[more]

PMID: 27455412

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