Ontology highlight
ABSTRACT:
SUBMITTER: Palma LM
PROVIDER: S-EPMC4835139 | biostudies-literature | 2016
REPOSITORIES: biostudies-literature
Palma Lilian M Pereira LM Langman Craig B CB
Journal of blood medicine 20160412
The biology of atypical hemolytic uremic syndrome has been shown to involve inability to limit activation of the alternative complement pathway, with subsequent damage to systemic endothelial beds and the vasculature, resulting in the prototypic findings of a thrombotic microangiopathy. Central to this process is the formation of the terminal membrane attack complex C5b-9. Recently, application of a monoclonal antibody that specifically binds to C5, eculizumab, became available to treat patients ...[more]